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KMID : 0870420010050020113
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Korean Journal of Hepato-Biliary-Pancreatic Surgery
2001 Volume.5 No. 2 p.113 ~ p.117
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Hepatocellular Carcinoma of the Liver with Sarcomatous Feature
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Shin Dong-Hoon
Kang Won-Geun
Yoon Myung-Hee
Chun Bong-Kwon
Oh Kyung-Seung
Lee Chung-Han
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Abstract
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One case of hepatocellular carcinoma with sarcomatous changes is presented. Histologically, the tumor was composed of hepatocellular-carcinomatous and sarcomatous components, including trabecular, pseudoglandular, and spindle-shaped varieties. There was a transitional cell form between the carcinoma and sarcomatous cells. Immunohistochemical examination for alpha-feto protein reveals positive staining in hepatocellular carcinoma component, and vimentin had positive result in most spindle-shaped sarcomatous cells and some epithelial tumor cells, whereas cytokeratin and EMA(epithelial membrane antigen) revealed negative staining in tumor cells, On the basis of this findings, the possibility of sarcomatous transformation of hepatocellular carcinoma was discussed.
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KEYWORD
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Hepatocellular carcinoma, Sarcomatous transformation, Immunohistochemistry, Cytokeratin, EMA (epithelial membrane antigen), Vimentin
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